中国药房2017，Vol.28Issue(33)：4637-4639,3.DOI:10.6039/j.issn.1001-0408.2017.33.08
氟尿嘧啶植入剂对进展期胃癌患者腹腔化疗安全性的考察
Observation of Fluorouracil Implants on the Intraperitoneal Chemotherapy Safety of Advanced Gastric Cancer Patients
摘要
Abstract
OBJECTIVE:To investigate the effects of Fluorouracil implants on intraperitoneal chemotherapy safety of advanced gastric cancer patients. METHODS:The information of 264 patients with advanced gastric cancer were analyzed retrospectively. All patients were given Fluorouracil implants 800 mg,scattered into the mesenteric and surgical area,dose of each implantation site less than 200 mg,the distance of implantation range from incision and anastomosis more than 3 cm. All patients were given second generation cephalosporin 30 min before operation,at 3rd h during operation,1-3 d after operation. The occurrence of complications and ADR during hospitalization were observed after operation. RESULTS:After operation,6 patients suffered from complications, with incidence of 2.28%,including 3 cases of gastrointestinal reaction,2 cases of anastomotic bleeding and 1 case of anastomotic leakage. Routine blood test and liver and kidney function were rechecked 3 d after operation,mainly thrombocytopenia and liver function injury,with the incidence of 2.65%. CONCLUSIONS:Fluorouracil implants can be used for intraperitoneal chemotherapy of advanced gastric cancer patients. However,attention should be paid to thrombocytopenia and liver function injury.关键词
进展期胃癌/氟尿嘧啶植入剂/腹腔化疗/毒性反应/安全性Key words
Advanced gastric cancer/Fluorouracil implants/Intraperitoneal chemotherapy/Toxic reaction/Safety分类
医药卫生引用本文复制引用
陈秀峰,邹妤婕,陈利辉,魏珂,王帅奇,刘苗,李卫,孙浩..氟尿嘧啶植入剂对进展期胃癌患者腹腔化疗安全性的考察[J].中国药房,2017,28(33):4637-4639,3.基金项目
重庆市医学科研计划项目(No.2012-2-512) （No.2012-2-512）
