中国药房2017，Vol.28Issue(33)：4675-4678,4.DOI:10.6039/j.issn.1001-0408.2017.33.19
替吉奥联合艾迪注射液治疗晚期胃癌的Meta分析
Meta-analysis of Aidi Injection Combined with S-1 for Advanced Gastric Cancer
摘要
Abstract
OBJECTIVE:To evaluate therapeutic efficacy and safety of Aidi injection combined with S-1 for advanced gastric cancer systematically,and to provide evidence-based reference. METHODS:Retrieved from CJFD,Wanfang database,VIP, CBM,Cochrane Library,PubMed and EMBase,randomized controlled trials(RCTs)about Aidi injection combined with S-1(tri-al group) vs. S-1 alone (control group) for advanced gastric cancer were collected. Meta-analysis was conducted by Rev Man 5.3 software after data extraction and quality evaluation by risk bias evaluation tool of Cochrane Handbook Version 5.1.0. RESULTS:A total of 8 RCT were included,involving 690 patients. Results of Meta-analysis showed that there was no statistical significance in therapeutic efficacy of solid tumor between 2 groups [OR=1.19,95%CI(0.88,1.61),P=0.26]. The improvement rate of survival quality[OR=3.62,95%CI(2.48,5.30),P<0.001],immunoglobulin level [CD3:SMD=1.31,95%CI(1.06,1.56),P<0.001;CD4:SMD=1.71,95%CI(1.38,2.04),P<0.001;CD8:SMD=-1.46,95%CI(-1.68,-1.23),P<0.001;CD4/CD8:SMD=1.45,95%CI(1.14,1.76),P<0.001] in trial group was significantly higher than control group. The incidence of leukopenia [RR=0.52,95%CI (0.40,0.68),P<0.001],thrombocytopenia [RR=0.49,95%CI(0.36,0.67),P<0.001] and gastrointestinal disorder [RR=0.56,95%CI(0.43,0.71),P<0.001] in trial group were significantly lower than control group,with statistical significance. CONCLUSIONS:Compared to S-1 alone,S-1 combined with Aidi injection can not significantly improve therapeutic efficacy of solid tumor therapy, but can improve survival quality and immunity of patients,as well as reduce the occurrence of ADR.关键词
艾迪注射液/替吉奥/胃癌/Meta分析/疗效/副反应Key words
Aidi injection/S-1/Gastric cancer/Meta-analysis/Therapeutic efficacy/Side reaction分类
医药卫生引用本文复制引用
池志恒,虞舜,崔蒙..替吉奥联合艾迪注射液治疗晚期胃癌的Meta分析[J].中国药房,2017,28(33):4675-4678,4.基金项目
江苏高校协同创新中心课题(No.苏政办发〔2014)22号) （No.苏政办发〔2014）
江苏省优势学科建设工程项目(No.苏政办发〔2014)37号) （No.苏政办发〔2014）
