中国药业2017，Vol.26Issue(23)：31-33,3.DOI:10.3969/j.issn.1006-4931.2017.23.010
氟西汀和帕罗西汀改善青少年抑郁症患者认知功能比较研究
Comparative Study of Fluoxetine and Paroxetine in Improving Cognitive Function in Adolescent Patients with Depression
摘要
Abstract
Objective To compare the clinical efficacy of fluoxetine and paroxetine in the treatment of cognitive function in adolescent patients with depression. Methods Totally 50 adolescent patients with depression in Chongqing Mental Health Center from 2013 to 2015 were selected and randomly divided into the fluoxetine group and the paroxetine group, 25 cases in each group. Before treatment and after 8 weeks of treatment, the severity of the disease in two groups was assessed by the Hamilton Depression Scale 24 ( HAMD-24 ) , the executive and memory functions of two groups were assessed by the Wisconsin Card Sorting Test ( WCST ) and the clinical memory scale (CMS) . Results Compare with before treatment, the total scores of HAMD-24, the factors of WCST and CMS in the two groups were significantly different ( P < 0. 01 ) . Before and after treatment, the total scores of HAMD-24, the number of total test correct responses and error responses of the factors of CMS and WCST had no difference between the two groups ( P > 0. 05 ) . There were statistical differences in the number of completed categories of the WCST between the two groups ( P < 0. 05 ) . Conclusion Fluoxetine and paroxetine can im-prove symptoms and cognitive function in adolescent patients with depression, but paroxetine is superior to fluoxetine.关键词
氟西汀/帕罗西汀,青少年/抑郁症/认知功能/临床疗效Key words
fluoxetine/paroxetine/adolescent/depression/cognitive function/clinical effect分类
医药卫生引用本文复制引用
刘小林,符巍..氟西汀和帕罗西汀改善青少年抑郁症患者认知功能比较研究[J].中国药业,2017,26(23):31-33,3.基金项目
重庆市卫生局面上项目[ 2012-2-248 ]. （）
