摘要
Abstract
Objective To investigate the clinical effect of carbonic anhydride inhibitors on corneal endothelial cells after phacoemulsification. Methods Totally 90 cataract patients ( 103 eyes ) underwent phacoemulsification in our hospital from January 2013 to January 2015 were selected and randomly divided into the observation group ( 50 cases, 60 eyes ) and the control group ( 40 cases, 43 eyes ) . The control group was given to Tobramycin and Dexamethasone Ophthalmic Suspension, while the observation group was given brinzolamide. The endothelial cell density and corneal thickness were observed and compared between the two groups before and after treatment. Results Compared with the control group, the number of corneal endothelial cells of patients in the observation group was significantly higher in the 3, 6, 9 months after the operation ( P < 0. 05 ) . Compared with before the operation, the number of corneal endothelial cells in the observation group was significantly higher in the 3, 6 months after the operation ( P < 0. 05 ) . 9 months after operation, the corneal endothelial cells counts of the two groups had no significant difference with before operation ( P > 0. 05 ) . 1 d, 3 d, 1 week after opera-tion, the corneal thickness of the observation group was significantly thicker than that of the control group ( P < 0. 05 ) , 1 d, 3 d, 1 week after operation , the corneal thickness of the observation group was significantly thicker than that before operation ( P < 0. 05 ) . Conclusion Carbonic anhydrase inhibitor has a positive effect on corneal endothelial cells after phacoemulsification, which can protect corneal cells from injury and restore corneal cell function.关键词
碳酸酐酶抑制剂/白内障超声乳化术/角膜内皮细胞/临床疗效Key words
carbonic anhydrase inhibitor/phacoemulsification/corneal endothelial cells/clinical effect分类
医药卫生
