中国药业2017，Vol.26Issue(23)：67-71,5.DOI:10.3969/j.issn.1006-4931.2017.23.023
抗菌药物轮替政策对医院革兰阴性菌耐药性的影响分析
Influence of Antibiotic Rotation Policy on Antibiotic Resistance of Gram Negative Bacteria in a Hospital
王梓 1王锦文 1李雪松2
作者信息
- 1. 云南省第二人民医院临床药学部,云南昆明 650021
- 2. 昆明医科大学第一附属医院科技教育部,云南昆明 650000
- 折叠
摘要
Abstract
Objective To analyze the influence of antibiotic rotation policy ( ARP ) on relevance ratio and antibiotic resistance rate of gram negative bacteria. Methods The antibiotic resistance rate of Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosae and Acinetobacter baumannii were compared before and after the ARP practiced in The Second People′s Hospital of Yunnan Province. Results After the first round of ARP, the antibiotic resistance rate of Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosae and Acinetobacter baumannii to ceftazidime, cefepime and aztreonam which had been ceased during ARP were descending, and the trend was the same in some other kind of antibiotics, while the resistance of Klebsiella pneumonia to carbapenems increased simultaneously. After ceftazidime and cefepime had been desterilized, the resistance of gram-negative bacteria was stable or significantly risen. Conclusion After the implementation of ARP, the resistance rate of gram negative bacteria decreased, and it tends to be stable or rising when those antibiotics were desterilized.关键词
抗菌药物轮替政策/革兰阴性菌/耐药性/头孢他啶/头孢吡肟/细胞耐药监测/药物敏感性试验/感染控制Key words
antibiotic rotation policy/gram-negative bacteria/antibiotic resistance/ceftazidime/cefepime/surveillance of bacterial resistance/drug sensitivity test/infection control分类
医药卫生引用本文复制引用
王梓,王锦文,李雪松..抗菌药物轮替政策对医院革兰阴性菌耐药性的影响分析[J].中国药业,2017,26(23):67-71,5.
