中华耳科学杂志2017，Vol.15Issue(5)：542-545,4.DOI:10.3969/j.issn.1672-2922.2017.008.
突发性聋免疫损伤证据:MMP-9表达下调及意义
Evidence of Immunologic Injury in Sudden Sensorineural Hearing Loss:Down Regulation of Serum MMP-9 Expression and Its Significance
摘要
Abstract
Objective Matrix metalloproteinase 9 (MMP-9) has been shown to be associated with immune injury in systemic lupus erythematosus (SLE). This study aims to test the concentration of serum MMP-9 in patients with sud-den sensorineural hearing loss (SSNHL) and to investigate whether there is a similar MMP-9 associated injury mecha-nism in this disease. Methods Forty-three patients with SSNHL and 23 healthy volunteers were studied from November 2015 to January 2016. Serum MMP-9 was tested by ELISA. Results Average serum MMP-9 concentration was 310.85 ±218.27 ng/ml in the control group, compared with the much lower 73.45±51.59 ng/ml in the experiment group, (56.28± 39.22 ng/ml in those with low frequency SSNHL, 86.30 ± 49.91 ng/ml in those with high frequency SSNHL, 61.01 ± 47.77 ng/ml in those with flat type SSNHL, and 85.51 ± 58.69 ng/ml in those with total deafness) (H=32.526, P<0.01). Serum MMP-9 levels were not significantly different among different SSNHL types (P>0.05). Conclusions Decrease of serum MMP-9 in patients with SSNHL may be related to excessive consumption in the process of auto-immune dam-age in the inner ear. It is speculated that MMP-9 may participate in the occurrence and development of the disease via immune injury.关键词
突发性聋基质金属蛋白酶9免疫损伤Key words
Sudden Sensorineural Hearing Loss/Matrix Metalloproteinase 9/Immune Injury.分类
医药卫生引用本文复制引用
卢韬,康厚墉,胡国华,钱怡,邹祺缘,庞颖,曾继红..突发性聋免疫损伤证据:MMP-9表达下调及意义[J].中华耳科学杂志,2017,15(5):542-545,4.基金项目
国家自然科学基金(编号:81170926) the National Natural Science Foundation of China(No. 81170926) （编号:81170926）
