中成药2017，Vol.39Issue(11)：2255-2258,4.DOI:10.3969/j.issn.1001-1528.2017.11.006
麝香乌龙丸对RA患者外周血miR-146a、miR-130及miR-223表达水平的影响
Effects of Shexiang Wulong Pills on the expression levels of miR-146a, miR-130 and miR-223 of peripheral blood in patients with RA
摘要
Abstract
AIM To explore the effects of Shexiang Wulong Pills (Moschus Artifactus,Aconiti Radix Cocta,Pheretima,etc.) drug serum on the expression levels of miR-146a,miR-130 and miR-223 in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA).METHODS PBMCs were extracted from blood of 30 cases of RA patients,cells were divided into three groups,blank control group,serum-free groupand Shexiang Wulong Pills drug serum group.After 48 hours,total RNA was extracted,then the expression levels of three miRs were detected by RT-PCR.RESULTS Compared with the serum-free group,the expression levels of miR-146a,miR-130 and miR-223 in the Shexiang Wulong Pills drug serum group were significantly decreased (P ＜ 0.01).CONCLUSION Shexiang Wulong Pills can inhibit inflammation in RA patients by down-regulating the expression levels of miR-223,miR-130 and miR-146a in PBMCs.关键词
麝香乌龙丸/类风湿关节炎(RA)/miR-146a/miR-130/miR-223Key words
Shexiang Wulong Pills/rheumatoid arthritis (RA)/miR-146a/miR-130/miR-223分类
医药卫生引用本文复制引用
王志文,王松松,崔建美,曹颖,徐丁洁,袁强,于笑涵,任晨晖,仲伟静..麝香乌龙丸对RA患者外周血miR-146a、miR-130及miR-223表达水平的影响[J].中成药,2017,39(11):2255-2258,4.基金项目
河北省重大医学科研课题资助项目(ZYZ2013017) （ZYZ2013017）
