中成药2017，Vol.39Issue(11)：2273-2278,6.DOI:10.3969/j.issn.1001-1528.2017.11.010
夏枯草有效组分结肠靶向微丸的制备及其体外释药行为
Preparation of colon-targeted pellets of Prunellae Spica effective components and the in vitro drug-release behaviors
摘要
Abstract
AIM To prepare colon-targeted pellets of Prunellae Spica effective components and to evaluate the in vitro drug-release behaviors.METHODS Fluidized bed coating method was adopted in the preparation of pellets.With in vitro accumulative release rate as an evaluation index,hydroxypropyl methyl cellulose (HMPC),polyacrylic resin (Eudragit S100) and triethyl citrate (TEC) amounts as influencing factors,orthogonal test was applied to optimizing the formulation.The in vitro drug-release behaviors were evaluated with rosmarinic acid content as an index.RESULTS The optimal formulation was determined to be 5％ for HPMC amount,70％ for Eudragit S100 amount,and 20％ for TEC amount.The obtained pellets attained an accumulative release rate of more than 90％ in pH 7.6 PBS (transportation for 2 h),while no drug dissolution was found in pH 1.0 HCl (transportation for 2 h) or pH 6.8 PBS (transportation for 3 h).CONCLUSION Colon-targeted pellets of Prunellae Spica effective components can achieve in vitro colon-targeted effect.关键词
夏枯草/有效组分/结肠靶向微丸/体外释药行为/流化床包衣法/正交试验Key words
Prunellae Spica/effective components/colon-targeted pellets/in vitro drug-release behaviors/fluidized bed coating method/orthogonal test分类
医药卫生引用本文复制引用
张建伟,刘力,王琴,徐德生..夏枯草有效组分结肠靶向微丸的制备及其体外释药行为[J].中成药,2017,39(11):2273-2278,6.基金项目
上海市科委“科技创新行动计划”生物医药领域科技支撑项目(13401900302) （13401900302）
上海市进一步加快中医药事业发展三年行动计划(ZY3-JSFC-2-3004) （ZY3-JSFC-2-3004）
