肿瘤防治研究2017，Vol.44Issue(11)：764-768,5.DOI:10.3971/j.issn.1000-8578.2017.17.0273
胶质瘤干细胞微环境及其治疗靶点的研究进展
Research Progress of Glioma Stem Cells Microenvironment and Therapeutic Targets
摘要
Abstract
Glioblastoma is the most common and devastating primary brain tumor,with only 15-19 months.It has been confirmed that glioma stem cells (GSCs) is one type of cancer stem cells in malignant glioma showing the abilities of self-renewal,unlimited proliferation and multi-directional differentiation of neural stem-like cells.GSCs may play a critical role in the resistance to conventional treatment and tumor relapse.The microenvironment,composed of interstitial cells and body fluid components,regulates the proliferation,differentiation,apoptosis,drug resistance and other mechanisms in GSCs.It does necessarily affect the characteristics of stem cells and tumor malignant phenotype.In recent years,significant progress has been made,opening new avenues in investigating the mechanisms of growth,invasion and migration of glioma and its interaction with microenvironment.This review focuses on the impact of microenvironment including abnormal vasculature,hypoxia and immunosuppression on GSCs,and its potential therapeutic targets for selective inhibition of GSCs.关键词
胶质瘤干细胞/血管微环境/缺氧微环境/免疫微环境/治疗靶点Key words
Glioma stem cells/Vascular microenvironment/Hypoxic microenvironment/Immune microenvironment/Therapeutictargets分类
医药卫生引用本文复制引用
许蓓,江高峰,李爱群..胶质瘤干细胞微环境及其治疗靶点的研究进展[J].肿瘤防治研究,2017,44(11):764-768,5.基金项目
国家自然科学基金(81572495,81573239) （81572495,81573239）
武汉市中青年医学骨干人才培养工程 （）
