中山大学学报（医学科学版）2017，Vol.38Issue(6)：854-859,885,7.
CYP2C19基因多态性与症状性颅内动脉狭窄患者氯吡格雷反应性及早期神经功能恶化的相关性
Relationship between Clopidogrel Response ,Early Neurological Deterioration and CYP2C19 Gene Polymorphism in Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)Patients
摘要
Abstract
[Objective]To investigate the relationship between clopidogrel response , early neurological deterioration and CYP2C19 gene polymorphism in sICAS patients.[Methods]116 sICAS patients were divided into deterioration group and non-deterio?ration group by whether appear early nervous function deterioration. Record included the baseline data,the genotypes of CYP2C19, platelet maximum aggregation rate after 7 days of given clopidogrel,CYP2C19 genotype and clopidogrel reaction were compared be?tween two groups.[Results]The deterioration group combination with diabetes ,stroke/TIA were significantly higher than the non-de?terioration group(P<0.05);The frequency of CYP2C19*2 AA genotype and A allele were significantly higher than those in non-dete?rioration group. The frequency of GG genotype were significantly lower than non-deterioration group (27.27% vs 2.13%,50.00% vs 14.84%,27.27% vs 72.34%)(P<0.01);The poor metabolic genotype platelet maximum aggregation rate were significantly higher than that of the fast-metabolic genotype and middle metabolic genotype(P<0.01,P<0.05),Middle metabolic genotype platelet maxi?mum aggregation rate were significantly higher than fast-metabolic genotype(P<0.01);The deterioration group fast-metabolic geno?type were significantly lower than non-deterioration group ,poor metabolic genotype were significantly higher than non-deterioration group(22.73% vs 65.96%,36.36% vs 5.32%)(P<0.01);Clopidogrel resistance rate 59.09% were significantly higher non-deteriora?tion group 28.72%(P<0.05).[Conclusion]Clopidogrel response and early neurological deterioration in sICAS patients is associatedwith CYP2C19 gene polymorphism.关键词
症状性颅内动脉狭窄/CYP2C19基因/氯吡格雷/基因多态性Key words
symptomatic intracranial atherosclerotic stenosis/CYP2C19 gene/clopidogrel/gene polymorphism分类
医药卫生引用本文复制引用
高晗清,薛群,段晓宇,朱珏华,方琪..CYP2C19基因多态性与症状性颅内动脉狭窄患者氯吡格雷反应性及早期神经功能恶化的相关性[J].中山大学学报（医学科学版）,2017,38(6):854-859,885,7.基金项目
国家自然科学基金青年基金(81601011) （81601011）
