摘要
Abstract
Objective To observe the efficacy of Yishen Huoxue Huatan Recipe(YHHR) on type 2 diabetes mellitus(T2DM) and carotid atherosclerosis (CAS).Methods The patients with T2DM and CAS were randomly assigned to the treatment group (132 cases) and the control group (136 cases).The final cases included 124 cases in the treatment group and 133 cases in the control group.Patients in the control group were treated with Western medicine,while the treatment group was treated with YHHR on the basis of the treatment in the control group.After the administration of the two groups for 12 weeks,Chinese Medicine(CM) syndrome curative effect was conducted.The intima-media thickness (IMT) of carotid artery,number of carotid plaque,blood flow velocity of carotid artery [including diastolic minimum velocity of arteria carotis communis (Vmin),systolic maximum velocity (Vmax),resistance index (RD)] and serum biochemical indexes[including fasting blood-glucose (FBG),glycosylated hemoglobin (HbA1 c),total cholesterol (TC),low density lipoprotein (LDL-C),triglycerides (TG)] were detected.Results After treatment,total effective rate of TCM syndrome was 54.14％ (72/133) for the control group,65.32 ％ (81/124) for the treatment group,total effective rate in the treatment group was higher than that in the control group (P ＜0.05).Compared with that before treatment,the level of TC,TG,LDL,FBG and HbA1c after treatment in the two groups decreased,and the IMT of carotid artery,number of carotid plaque,RD in the treatment group and the number of carotid plaque in control group decreased.While Vmax and Vmin in the treatment group increased (P ＜0.05).Compared with that in the same period of the control group,the IMT of carotid artery,number of carotid plaque,RD in the treatment group decreased,and Vmax in the treatment group increased (P ＜0.05).Conclusion YHHR may be effecitve on patients with T2DM and CAS in aspects of clinical biochemical indexes,CM syndrome,IMT of carotid artery,number of carotid plaque,blood flow velocity,blood flow resistance index and etc.关键词
益肾活血化痰方/2型糖尿病/颈动脉粥样硬化Key words
Yishen Huoxue Huatan Recipe/type 2 diabetes mellitus/carotid atherosclerosis
