中国中西医结合杂志2017，Vol.37Issue(11)：1330-1333,4.DOI:10.7661/j.cjim.20171013.240
消溃散联合复方甲硝唑漱口液治疗乳腺癌患者口服依维莫司所致口腔溃疡的临床研究
Clinical Observation of Xiaokui Powder Combined with Compound Metronidazole Collutory Treating Everolimus-induced Oral Ulcer Patients with Breast Cancer
摘要
Abstract
Objective To investigate the clinical efficacy of Xiaokui powder combined with compound metronidazole collutory on everolimus-induced oral ulcer.Methods Thirty cases of advanced breast cancer patients with everolimus-induced oral ulcer were assigned to treatment group and control group with 15 cases in each group according to the random number table.The patients in the control group were treated by compound metronidazole collutory.The patients in the treatment group were treated by compound metronidazole collutory and Xiaokui powder.Two groups started medication from the occurrence of oral ulcer within 24 hours.The ulcer surface and pain score were measured on day 1,3 and 5.The overall effective rate of oral ulcer healing,degree of pain relief,pain score and the healing time of oral ulcer were observed and recorded.Results In the treatment group,the response rate of oral ulcer healing was 85.7％(12/14),higher than 64.3％ in the control group(9/14,P ＜0.05).The pain remission rate of treatment group was 100％ (14/14),which was significantly superior to that of the control group(9/14,64.3％).Compared with the group before treatment,the pain scores on day 5 in the control group and on day 3,5 in the treatment group were decreased(P ＜0.05).Compared with the control group,the pain score of the treatment group on day 3 and day 5 decreased significantly (P ＜0.05).The average healing time of oral ulcer in treatment group was shorter than that of control group(P ＜0.05).Conclusion The Xiaokui powder combined with compound metronidazole collutory could effectively relieve oral pain and accelerate ulcer healing time in treating everolimus-induced oral ulcer.关键词
消溃散/复方甲硝唑漱口液/依维莫司/口腔溃疡Key words
Xiaokui powder/compound metronidazole collutory/everolimus/oral ulcer引用本文复制引用
肖寒,方乃青,邬晓敏,奚柯婧,李慧刚..消溃散联合复方甲硝唑漱口液治疗乳腺癌患者口服依维莫司所致口腔溃疡的临床研究[J].中国中西医结合杂志,2017,37(11):1330-1333,4.基金项目
江苏省无锡市医管中心项目(No.YGZXM1403) （No.YGZXM1403）
