北京生物医学工程2017，Vol.36Issue(6)：619-625,7.DOI:10.3969/j.issn.1002-3208.2017.06.012
粪菌移植治疗溃疡性结肠炎临床缓解率的影响因素分析
Influence factor analysis of clinical remission rate of fecal bacteria transplantation for the treatment of ulcerative colitis
汤井双 1徐为2
作者信息
- 1. 徐州医科大学 江苏徐州 221002
- 2. 沭阳县人民医院普外科 江苏沭阳 223600
- 折叠
摘要
Abstract
Objective This Meta?analysis aims to quantitatively evaluate the effects of different factors on the clinical remission rate of fecal microbiota transplantation for ulcerative colitis. Methods Domestic and international databases were screened and Meta?analysis was used to analyze the effects of different factors on the clinical remission rate of fecal microbiota transplantation for ulcerative colitis. The inventory of quality evaluation for cases recommended by National Institute for Health and Clinical Excellence( NICE) of Britain was employed in the literature quality evaluation. Estimations were pooled by fixed effect models according to the results of heterogeneity test. Results A total of 11 literature involving 133 patients were included. Meta?analysis showed that the clinical remission rate of FMT for UC was 28. 6％( 38/133 ) , and the remission rate was 30. 4％( 95％CI:22. 6％ ～ 39. 4％) . A subgroup analysis suggested that the clinical remission rate of lower gastrointestinal delivery and upper gastrointestinal delivery were 29. 8％(95％CI:20. 2％ ～ 41. 6％)and 27. 5％(95％CI:16. 1％ ～ 42. 9％)respectively,and there was no difference between the two groups(χ2=0. 002,P=0. 963). Furthermore,subgroup analysis revealed that the clinical remission rate of single infusion and multiple infusions were 28. 2％( 95％CI:20. 5％～43. 3％) and 28. 9％( 95％CI:20. 1％～39. 7％) respectively, and there was no difference between the two groups (χ2 =0. 020,P=0. 887). Conclusions FMT has certain curative effect in the treatment of UC. It is necessary to carry out large?scale multicenter,large?sample randomized controlled trials to standardize FMT treatment.关键词
粪菌移植/溃疡性结肠炎/因素/缓解率/Meta分析Key words
fecal microbiota transplantation/ulcerative colitis/factor/remission rate/Meta analysis分类
医药卫生引用本文复制引用
汤井双,徐为..粪菌移植治疗溃疡性结肠炎临床缓解率的影响因素分析[J].北京生物医学工程,2017,36(6):619-625,7.
