北京大学学报（医学版）2017，Vol.49Issue(6)：1034-1037,4.DOI:10.3969/j.issn.1671-167X.2017.06.017
术中冰冻或术后石蜡病理报告T1b期胆囊癌的外科治疗策略
Surgical strategies for treatment of T1b gallbladder cancers diagnosed intraoperatively or postoperatively
张铃福 1侯纯升 1郭丽梅 2陶立元 3凌晓锋 1王立新 1徐智 1修典荣1
作者信息
- 1. 北京大学第三医院普外科,北京100191
- 2. 北京大学第三医院病理科,北京100191
- 3. 北京大学第三医院临床流行病学研究中心,北京100191
- 折叠
摘要
Abstract
Objective:To explore the surgical strategies for the treatment of T1 b gallbladder cancer patients diagnosed intraoperatively or postoperatively.Methods:A retrospective analysis of 42 patients with T1 b gallbladder cancers was performed.There were 14 patients diagnosed intraoperatively and 28 patients diagnosed postoperatively.The reevaluations of T stages were conducted in the 28 T1 b gallbladder cancer patients diagnosed postoperatively by the professional pathologist.After T stage reevaluation,25 confirmed T1 b patients with complete follow-up data were divided into simple cholecystectomy group and radical resection group,and the clinicopathologic characteristics between the two groups were analyzed.Results:Only 2 of the 14 T1 b gallbladder cancer patients diagnosed by the intraoperative frozen specimen proved to be T1b on postoperative paraffin pathology,and for the remaining 13 patients,T2 was in 11 patients,and T3 in one patient.The rate of misdiagnosis was 85.7％ by the intraoperative frozen specimens,postoperative T stages were equal or higher than intraoperative T stages.Two of the 28 postoperatively diagnosed T1b patients were proved to be T2 after reevaluation,the rate of misdiagnosis was 7.1％,the reevaluated T stages were equal to or higher than the previous stages.Twenty-five confirmed T1 b gallbladder cancer patients had complete follow-up data,11 of whom underwent simple cholecystectomy and the remaining 14 radical resections.No patient had vessel or perineural invasion on pathology in the 25 confirmed T1b patients.Metastasis was absent in all the 30 lymph nodes examined,which achieved from 14 patients with radical resection.The survival rate after simple cholecystectomy was comparable to that after radical resection (P =0.361).Only one patient with radical resection had abdominal cavity implantation relapse,who received gallbladder compression during operation and 2 years later died from metastasis.Conclusion:Intraoperatively diagnosed T1 b gallbladder cancer should receive radical resection.Reevaluation of the T stage is necessary and the initial step for postoperative diagnosed T1b gallbladder cancer patients.The pros and cons of radical surgery for definitive T1b patients should be carefully evaluated,and systemic chemotherapy is recommended for those with bile spillover.关键词
胆囊肿瘤/肿瘤分期/外科手术/胆囊切除术,腹腔镜/预后Key words
Gallbladder neoplasms/Neoplasm staging/Surgical procedures, operative/Cholecystectomy, laparoscopic/Prognosis分类
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张铃福,侯纯升,郭丽梅,陶立元,凌晓锋,王立新,徐智,修典荣..术中冰冻或术后石蜡病理报告T1b期胆囊癌的外科治疗策略[J].北京大学学报（医学版）,2017,49(6):1034-1037,4.
