重庆医学2017，Vol.46Issue(34)：4802-4804,3.DOI:10.3969/j.issn.1671-8348.2017.34.015
HIF-2α及VEGF在结直肠癌组织中的表达及与患者预后的关系
Expression of HIF-2α and VEGF in colorectal cancer and its relationship with prognosis
黄澄澄 1唐成佳 2余天雾3
作者信息
- 1. 重庆医科大学附属永川医院老年病科 402160
- 2. 重庆医科大学附属永川医院肝胆外 402160
- 3. 重庆医科大学附属永川医院普外科 402160
- 折叠
摘要
Abstract
Objective To study the expression of HIF-2α and VEGF in colorectal cancer and to investigate the relationship between them and clinicopathologic parameter.Methods Immunohistochemistry staining was conducted to detect the expression of HIF-2α and VEGF protein in 67 samples of colorectal tumor tissues and 67 samples of normal adjacent tissue.Results The expression of HIF-2α and VEGF in colorectal cancer tissues was significantly higher than that in adjacent tissues.The expression of HIF-2α and VEGF increased with the clinical stage and lymph node metastasis.The expression of HIF-2α increased with the tumor volume.The expression of HIF-2α and VEGF was not related to the age,sex,tumor location and tumor differentiation of the patients.HIF-2α was positively correlated with VEGF expression.Kaplan-Meier survival analysis showed that HIF-2α expression was associated with survival,that is,the higher expression of HIF-2α the worse of prognosis was obtained.Conclusion HIF-2α is involved in the process of growth,invasion and metastasis of colorectal cancer.This process may be related to the regulation of VEGF expression.关键词
结直肠肿瘤/缺氧诱导因子2α/血管内皮生长因子AKey words
colorectal neoplasms/hypoxia-inducible factor 2α/vascular endothelial growth factor A分类
医药卫生引用本文复制引用
黄澄澄,唐成佳,余天雾..HIF-2α及VEGF在结直肠癌组织中的表达及与患者预后的关系[J].重庆医学,2017,46(34):4802-4804,3.
