摘要
Abstract
Objective:To observe the influence and curative effect of aripiprazole on serum cells factors levels of children with Tourette syndrome.Methods:Eighty-eight cases of children with Tourette syndrome were selected,and divided into experimental group and control group at random.The children in control group were given oral haloperidol from the beginning of 1.0 mg/d until the disappear of symptom or the max dose of 6.0 mg/d with once adding weekly,while the children in experimental group were given oral aripiprazole from the beginning of 2.5 mg/d until the disappear of symptom or the max dose of 10.0 mg/d with once adding weekly for 8 or more than 8 weeks.The changes of serum IL-6 and IL-8 and TNF-α levels of children in two groups were observed before and 8 weeks after medical treatment,and curative effect and adverse reactions were evaluated in accordance with YGTSS score and treatment emergent symptom scale (TESS) after medical treatment.Results:Three and five cases of loss to follow up were appeared on children in experimental group and control group respectively during treatment respectively,and after comparing the loss rates to follow up of children in two groups,no statistical difference was appeared (x2 =0.50,P＞0.05).After 8 weeks' treatment,serum IL-6 and IL-8 levels in two groups were obviously increased than before,and TNF-α levels in two groups were obviously decreased than before (P＜0.05),and the rising rates of children in experimental group were much higher than those in control group (P＜0.05).Meanwhile,the total clinical efficiency of children in experimental group (92.68％) was much higher than that in control group (76.32％,x2 =4.07,P＜0.05).The incidence of adverse reaction of children in experimental group was much lower than that in control group (x2 =4.39,P＜0.05) in accordance with TESS.Conclusion:Compared with haloperidol,aripiprazole has more favorable clinical curative effect and security in children with Tourette syndrome,whose mechanism of action may have close effect on raising serum IL-6 and IL-8 and decreasing serum TNF-α level to improve immune function and inhibit inflammatory response.关键词
Tourette综合征/儿童/阿立哌唑/氟哌啶醇/细胞因子Key words
Tourette syndrome/children/aripiprazole/haloperidol/cell factors分类
医药卫生
