华东理工大学学报（自然科学版）2017，Vol.43Issue(5)：597-605,9.DOI:10.14135/j.cnki.1006-3080.2017.05.001
基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子
Preparation of Size-Controllable Drug Loaded Nano Particles Based on Flash Nano Precipitation Method
摘要
Abstract
Five amphiphilic diblock copolymers,methoxy poly (ethylene glycol)-b-polycaprolactone (mPEG-b-PCL) with different molecular weights and hydrophilic/hydrophobic proportions were synthesized.A series of nano particles encapsulated model drug beta-carotene and protected by the prepared copolymers as surfactants were prepared by using flash nano-precipitation (FNP) method.The size and size distribution of nano particles were controllable by changing the block structure,molecular weight,polymer concentration and solvent ratio (V (H2O) ∶ V (THF)).Experimental results showed that the size of nano particles decreased by increasing the solvent ratio or hydrophilic proportion.Under the same proportion of the hydrophilic moieties,the size of particles was decreased by increasing the molecular weight.The nano particles became more stable and their size distribution was narrower upon increasing polymer concentrations.关键词
FNP/聚合物纳米粒子/尺寸可控Key words
FNP/polymeric nano particles/size-controllable分类
化学化工引用本文复制引用
马俊,李莉,王铭纬,周志明,郭旭虹..基于瞬时纳米沉淀法制备尺寸可控载药纳米粒子[J].华东理工大学学报（自然科学版）,2017,43(5):597-605,9.基金项目
国家自然科学基金(21476143) （21476143）
