中国实用神经疾病杂志2017，Vol.20Issue(20)：6-9,4.DOI:10.3969/j.issn.1673-5110.2017.20.002
N-乙酰半胱氨酸对帕金森病模型大鼠黑质氧化应激相关指标的影响
Effects of N-acetylcysteine on theoxidative stress correlation index in substantia nigra of Parkinson 's disease model rats
摘要
Abstract
Objective To observe the effects of N-acetylcysteine on the oxidative stress correlation index in substantia nigra of Parkinson's disease model rats.Methods 36 SD rats were randomly divided into sham-operated group(sham group) ,PD model group(PD group) and antioxidant NAC group (NAC group) ,Each group was divided into 4 days and 8 days subgroups after the success of model preparation.PD rat model was established by injecting rotenone in subcutaneous.The content of SOD ,GSH , GSH-Px and MDA in the substantia nigra were detected by Micro-enzyme.Results (1)Compared with the sham group ,the con-tent of GSH ,GSH-Px and SOD in the PD group were significantly reduced (all P<0.01) ,and in the 8 d group was lower than that in the 4 d group(all P<0.05);Compared with the PD group ,the content of GSH ,GSH-Px and SOD in NAC group was in-creased (all P<0.05) ,and in the 8 d group was higher than that in the 4 d group (all P<0.05).(2)Compared with the sham group ,the content of MDA in the PD group was significantly increased (all P<0.05) ,and in the 8 d group was higher than that in the 4 d group (P<0.05).Conclusion with the PD group ,the content of MDA in NAC group was significantlydecreased (all P<0.05) ,and in the 8 d group was lower than that in the 4 d group (P<0.05).Conclusions N-acetylcysteine can attenuate oxidative stress injury in Parkinson's disease model rats ,and has a protective effect on the nerve.关键词
帕金森病/N-乙酰半胱氨酸/氧化应激/谷胱甘肽/谷胱甘肽过氧化物酶/超氧化物歧化酶/丙二醛/黑质Key words
Parkinson's disease/N-acetylcysteine/Oxidative stress/Glutathione/Glutathione peroxidase/Superoxide dis-mutase/Malonaldehyde/Substantia nigra分类
医药卫生引用本文复制引用
徐佳莉,刘斌,胡馨月,董亚楠,崔颖..N-乙酰半胱氨酸对帕金森病模型大鼠黑质氧化应激相关指标的影响[J].中国实用神经疾病杂志,2017,20(20):6-9,4.基金项目
河北省医学科学研究重点课题(编号:20130064) （编号:20130064）
