中国实用神经疾病杂志2017，Vol.20Issue(20)：26-29,4.DOI:10.3969/j.issn.1673-5110.2017.20.006
PEAR1基因多态性对长期服用阿司匹林脑梗死患者复发的影响
The effects of PEAR1 gene polymorphisms on recurrence of stroke in long-term taking aspirin patients with cere-bral infarction
李建设 1孟轲 1赵剑婷 1马玉龙 1车振勇1
作者信息
- 1. 新乡市中心医院 ,河南 新乡 453000
- 折叠
摘要
Abstract
Objective To investigate the relationship between PEAR1 gene polymorphisms and the recurrence of stroke in long-term taking aspirin patients with cerebral infarction.Methods 114 long-term (≥1 year) taking aspirin patients after the first attack of cerebral infarction were recruited and divided into two groups according to whether the stroke recurred or not.The geno-types of PEAR1 were detected with PEAR1 gene chip.Results In the 114 patients ,three genotypes of PEAR1 were detected :wild type GG ,Mutant heterozygous GA and Mutant homozygote AA ,the frequencies were 50.9% ,42.1% and 7.0% ,respectively.The GG genotype frequency of the stroke recurred group was significantly lower than that of the non-stroke recurred group (23.8%vs.57.0% ,P<0.01) ,and the AA genotype frequency of the stroke recurred group was significantly higher than that of the non-stroke recurred group ( (28.6% vs.2.1% ,P<0.01).The GA genotype frequency was not significant difference between the 2 groups (47.6% vs.40.9% ,P>0.05).There were significant differences in age ,smoking ,LDL and diabetes (P<0.05).It was i-dentified that genetic variants of PEAR1 were associated with the recurrence of stroke by multiple logistic regression analysis (P=0.006).Conclusion The genetic variants of PEAR1were associated with the recurrence of stroke in long-term taking aspirin patients after the first attack of cerebral infarction ,mutant homozygote AA of PEAR1 increased the risk of stroke recurrence.关键词
阿司匹林/脑梗死/基因多态性/PEAR1Key words
Aspirin/Cerebral infarction/Gene polymorphisms/PEAR1分类
医药卫生引用本文复制引用
李建设,孟轲,赵剑婷,马玉龙,车振勇..PEAR1基因多态性对长期服用阿司匹林脑梗死患者复发的影响[J].中国实用神经疾病杂志,2017,20(20):26-29,4.
