华中师范大学学报（自然科学版）2017，Vol.51Issue(6)：782-785,4.DOI:10.19603/j.cnki.1000-1190.2017.06.010
新型帕唑帕尼衍生物的合成与活性初步研究
Synthesis and preliminary anticancer activity of novel pazopanib derivatives
摘要
Abstract
Based on the structure-activity relationship of pazopanib,four novel pazopanib derivatives were synthesized with 3-methyl-6-nitroindazole as raw materials.The structures of the compounds were identified by 1H NMR,LC-MS and elemental analyses,and the anti-proliferation activity of tumor cells were studied in vitro.MTT method was used to test the inhibition effect of proliferation activity of the target compounds on MGC803 cell.The results showed that the target compounds were able to inhibit the proliferation of MGC803 cells.关键词
抗肿瘤活性/酪氨酸激酶抑制剂/合成/帕唑帕尼衍生物Key words
antitumor activity/tyrosine kinase inhibitor/synthesis/pazopanib derivatives分类
化学化工引用本文复制引用
刘娥,李立威..新型帕唑帕尼衍生物的合成与活性初步研究[J].华中师范大学学报（自然科学版）,2017,51(6):782-785,4.基金项目
湖北省自然科学基金项目(2013CFA015) （2013CFA015）
药物合成与优化湖北省重点实验室开放基金项目(OPP2015YB04) （OPP2015YB04）
湖北省教育厅科研项目(Q20164303). （Q20164303）
