解放军医学杂志2017，Vol.42Issue(11)：945-950,6.DOI:10.11855/j.issn.0577-7402.2017.11.02
IL-25与变态反应性气道炎症
IL-25 and allergic airway inflammation
摘要
Abstract
Allergic airway inflammation is manifested as infiltration of CD4+ T cells and eosinophils in the airway,increased secretion of mucus,airway hyper-reactivity and airway remodeling.IL-25 is a member of the IL-17 family,which can promote and exacerbate Th2 cytokine-mediated airway inflammation after binding to its receptor IL-17RB.The increased IL-25 can induce the secretion of Th2 cytokines,including IL-4,IL-5 and IL-13,which may result in the local infiltration of eosinophils,airway hyperreactivity and therefore the injury of airway.As IL-25 plays an important role in allergic airway inflammation,the present paper would focus on the relationship between IL-25 and allergic airway inflammation.关键词
气道炎症/变态反应和免疫学/白细胞介素25/受体,白细胞介素25Key words
airway inflammation/allergy and immunology/interleukin-25/receptors, interleukin-25分类
医药卫生引用本文复制引用
何海欣,洪海裕..IL-25与变态反应性气道炎症[J].解放军医学杂志,2017,42(11):945-950,6.基金项目
广东省科技计划项目(2016A020215030)This work was supported by the Science and Technology Planning Project of Guangdong Province (2016A020215030) （2016A020215030）
