解放军医学杂志2017，Vol.42Issue(11)：956-961,6.DOI:10.11855/j.issn.0577-7402.2017.11.04
儿童阻塞性睡眠呼吸暂停低通气综合征与炎症的关系
Relationship between obstructive sleep apnea hypopnea syndrome and inflammation in children
摘要
Abstract
Objective To investigate the clinical efficacy of anti-inflammatory therapy (intranasal corticosteroids combined with oral leukotriene receptor antagonist) in pediatric mild to moderate obstructive sleep apnea hypopnea syndrome (OSAHS),and analyze the relationship between OSAHS and inflammation factors.Methods Fifty patients with mild to moderate OSAHS,diagnosed by polysomnography (PSG) during Jan.to Nov.2016,were enrolled in present study.The patients' medical history,data of special physical examination,paryngorhinoscopy,PSG and OSA-18 questionnaire were collected.Patients received the therapy of intranasal corticosteroids combined with oral leukotriene receptor antagonist for 12 weeks.Special physical examination,paryngorhinoscopy,PSG and OSA-18 questionnaire were reviewed and the data before and after treatment were compared.Results Of the 50 subjects,37 were with mild OSAHS and 13 with moderate OSAHS.A total of 19 cases (38％) were cured including 17 mild OSAHS and 2 moderate cases.Other 19 cases (38％) got therapeutic effect but not be cured.Twelve cases (24％) were invalid or aggravated.There were 10 patients (20％) who received surgical treatment after drug treatment.The average values of obstructive apnea index (OAI) and mixed apnea index (MAI) decreased significantly in mild group and only OAI decreased in moderate group.After treatment,the average volumes of adenoids and tonsils were significantly reduced in mild OSAHS children but not in moderate OSAHS children.The OSA-18 questionnaire score declined only in mild group.No obvious correlation existed between the change of tonsil volume and the parameters of PSG.Conclusion Anti-inflammatory therapy of intranasal corticosteroids combined with oral leukotriene receptor antagonist may obviously reduce the volumes of adenoids and tonsils,improve the PSG indexes and the life quality of OSAHS patients,especially for those children with mild OSAHS.关键词
睡眠呼吸暂停,阻塞性/腺样体/扁桃体肥大/儿童/投药,鼻内/糖皮质激素类/白三烯受体拮抗剂Key words
sleep apnea, obstructive/adenoid/tonsillar hypertrophy/child/administration, intranasal/glucocorticoids/leukotriene receptor antagonists分类
医药卫生引用本文复制引用
王桂香,张亚梅,何靖雅,张杰,赵靖,王华,许志飞,郑莉,王晨,李晓丹..儿童阻塞性睡眠呼吸暂停低通气综合征与炎症的关系[J].解放军医学杂志,2017,42(11):956-961,6.基金项目
北京市医院管理局重点医学专业发展计划(ZYLX201508)This work was supported by the Key Medical Professional Development Plan Sponsored by Beijing Hospital Management Bureau (ZYLX201508) （ZYLX201508）
