解放军医学杂志2017，Vol.42Issue(11)：962-967,6.DOI:10.11855/j.issn.0577-7402.2017.11.05
组蛋白去乙酰化酶在呼吸道相关疾病中的作用及展望
Research advances of histone deacetylases in inflammatory respiratory diseases
陈黛诗 1柯朝阳 2陈雷2
作者信息
- 1. 100853北京 解放军总医院耳鼻咽喉头颈外科
- 2. 518020深圳 深圳市人民医院耳鼻咽喉头颈外科、暨南大学附属第二临床医学院
- 折叠
摘要
Abstract
Histone deacetylases (HDAC) are pivotal enzymes in many physiological processes widely expressed in almost all tissues including chromatin remodeling,regulation of protein transcription,cell cycle,aging,oxidative stress,inflammation and expression of immune genes.Recent studies indicated that the equilibrium state of histone acetylation and deacetylation is closely related to respiratory tract inflammation,and the unbalanced expression of HDAC could induce the expression of genes related to the inflammatory cytokines and oxidative stress.Now the structure and classification of HDAC and the updated results on HDAC in the inflammatory respiratory diseases are herewith reviewed in present paper.关键词
组蛋白去乙酰化酶/慢性鼻窦炎/变应性鼻炎/慢性阻塞性肺疾病/哮喘Key words
histone deacetylases/chronic nasosinusitis/allergic rhinitis/chronic obstructive pulmonary disease/athsma分类
医药卫生引用本文复制引用
陈黛诗,柯朝阳,陈雷..组蛋白去乙酰化酶在呼吸道相关疾病中的作用及展望[J].解放军医学杂志,2017,42(11):962-967,6.
