实用临床医药杂志2017，Vol.21Issue(21)：12-14,18,4.DOI:10.7619/jcmp.201721003
非典型抗精神病药物对精神分裂症患者血清胶质源性神经营养因子水平的影响
Effect of atypical antipsychotics on glial cell line-derived neurotrophic factor levels in schizophrenia patients
摘要
Abstract
Objective To study effect of atypical antipsychotics on glial cell line-derived neurotrophic factor (GDNF) levels in schizophrenia patients.Methods A total of 104 drug-free schizophrenic patients and 70 healthy controls were recruited.All patients were treated with atypical antipsychotic monotherapy.GDNF serumlevels and psychiatric symptoms were assessed at baseline and at 2,4,6 and 8 weeks of treatment.Results Baseline serum GDNF levels were significantly lower in schizophrenic patients than healthy controls (t =5.596,P ＜ 0.001).GDNF levels gradually increased accompanied by a reduction in psychiatric symptoms during antipsychotic therapy (P ＜ 0.01).The levels of GDNF in responders were significantly changed after treatment (P ＜ 0.01),however,no significant change was found in non-responders (P ＞ 0.05).Furthermore,a negative association between GDNF levels after pharmacotherapy and disease duration in schizophrenic subjects could be observed (r =-0.270,P =0.024).Conclusion The present study suggests that GDNF may be involved in the mechanisms of schizophrenia pathogenesis and pharmacological efficacy.关键词
精神分裂症/胶质细胞源性神经营养因子/抗精神病药物Key words
schizophrenia/glial cell line-derived neurotrophic factor/antipsychotics分类
医药卫生引用本文复制引用
潘信明,胡雪峰,文璐,胡秀秀,张晓斌..非典型抗精神病药物对精神分裂症患者血清胶质源性神经营养因子水平的影响[J].实用临床医药杂志,2017,21(21):12-14,18,4.基金项目
江苏省第五期“333工程”科研资助项目(BRA2016555) （BRA2016555）
