摘要
Abstract
Objective To explore the efficacy and safety of escitalopram versus escitalopram plus dutoxetine in treatment of patients with post-schizophrenia depression.Methods A total of 120 patients with post-schizophrenia depression were randomly divided into dutoxetine group,escitalopram group and combination group,40 cases in each group.The HAMD-17 score,SF-36 score,total effective rate and adverse reactions before and after treatment were compared among three groups.Resuits Three and six weeks after treatment,the HAMD-17 score decreased significantly in three groups (P ＜ 0.05),and the HAMD-17 score of combination group was significantly lower than that of dutoxetine group and escitalopram group (P ＜ 0.05).Six weeks after treatment,the SF-36 score increased significantly in three groups (P ＜ 0.05),and the SF-36 score of combination group was significantly higher than that of dutoxetine group and escitalopram group (P ＜ 0.05).The total effective rate in combination group was 87.5％,which was significantly higher than 72.5％ in dutoxetine group and 75.0％ in escitalopram group (P ＜ 0.05).Incidence rates of adverse reactions were 30％,27.5％ and 32.5％ in duloxetine group,escitalopram group and combination group respectively.Conclusion Duloxetine combined with escitalopram can significantly improve symptoms of depression in patients with schizophrenia,increase the therapeutic efficiency,and improve the quality of life of patients.关键词
度洛西汀/艾司西酞普兰/精神分裂症/抑郁/疗效/安全性Key words
duloxetine/escitalopram/schizophrenia/depression/efficiency/safety分类
医药卫生
