检验医学与临床2017，Vol.14Issue(24)：3618-3620,3.DOI:10.3969/j.issn.1672-9455.2017.24.019
冠心病患者血浆Adropin蛋白与同型半胱氨酸水平的相关性研究
The correlation study between plasma adropin and homocysteine (Hcy) levels in patients with coronary artery disease
景月月 1白宏兴 1梁延宏 1薛恩忠 1景强强 1刘春丽1
作者信息
- 1. 陕西省延安市人民医院心内科 716000
- 折叠
摘要
Abstract
Objective To investigate the correlation between plasma adropin and homocysteine(Hcy)levels in patients with coro-nary artery disease ,and discuss their relationship with disease severity of coronary heart disease .Methods 170 cases of patients with coronary artery disease were collected from May 2014 to May 2016 in the hospital ,peripheral blood was collected for measur-ing plasma adropin ,homocysteine(Hcy) and other conventional biochemical indicators ,coronary artery lesions were detected by cor-onary angiography ,and the severity of coronary artery disease was assessed by SYNTAX score .Results The average serum homo-cysteine level of 170 patients was (15 .92 ± 8 .31)μmol/L ,and 76(44 .7％ )patients were identified as Hyperhomocysteinemia with a serum homocysteine level>15 μmol/L .The level of adropin in high Hcy group was lower than that of non-high Hcy group ,and BMI index ,SYNTAX scores and creatinine levels in high Hcy group were higher than those of non-high Hcy group ,and the differ-ences were statistically significant (P<0 .05) .The average SYNTAX score of all patients was (21 .51 ± 11 .20) ,plasma adropin lev-el was negatively correlated with Hcy level (r= -0 .169 ,P=0 .028) ,Hcy level had no significant correlation with SYNTAX score (r=0 .124 ,P=0 .108) ,and plasma adropin level was negatively correlated with SYNTAX score (r= -0 .181 ,P=0 .018) .General-ized structural equation model shows that with the decrease of plasma adropin level ,SYNTAX score was increased(P=0 .019) .Pa-tients with hyperhomocysteinemia had a significantly higher average SYNTAX score compared with those without hyperhomocys-teinemia(P=0 .005) .Conclusion Adropin level was negatively correlated with homocysteine (Hcy) level in patients with coronary heart disease .,The lower of the adropin level ,the higher of Hcy level ,the more severe situation of coronary artery disease .关键词
冠心病/Adropin蛋白/同型半胱氨酸/相关性Key words
coronary heart disease/adropin level/homocysteine/correlation引用本文复制引用
景月月,白宏兴,梁延宏,薛恩忠,景强强,刘春丽..冠心病患者血浆Adropin蛋白与同型半胱氨酸水平的相关性研究[J].检验医学与临床,2017,14(24):3618-3620,3.
