检验医学与临床2017，Vol.14Issue(24)：3626-3628,3.DOI:10.3969/j.issn.1672-9455.2017.24.022
硬膜外自控镇痛对老年髋关节置换术患者术后镇痛效果及IL-6、IL-10和TNF-α的影响
The postoperative sedation effect of patient-controlled epidural analgesia on elderly patients with hip arthroplasty and the effect on IL-6 ,IL-10 and TNF-α
刘辉 1李丕彬 1韩景田 1关芳 1张宪宦1
作者信息
- 1. 辽宁省抚顺矿务局总医院麻醉科 113008
- 折叠
摘要
Abstract
Objective To investigate and analyze the postoperative sedation effect of patient-controlled epidural analgesia on eld-erly patients with hip arthroplasty and the effect on inter leukin 6(IL-6) ,IL-10 and tumor necrosis factor(TNF-α) .Methods 110 cases of elderly patients with hip arthroplasty from May 2013 to March 2016 in the hospital were chosen as the research object .The patients were divided into the observation group and the control group according to number table method ,55 cases in each group . The patients in the observation group were treated with epidural analgesia while the control group was treated with intravenous an-algesia treatment .The effects of different analgesia methods on IL-6 ,IL-10 and TNF-alpha in two groups were observed and com-pared .Results After the implementation of different analgesia methods ,the analgesic effect was excellent in 32 out of 55 cases in the observation group (58 .18％ ) ,and the effective rate was 98 .18％ ,which were significantly higher than those in the control group that the excellent analgesic effect in 18 cases and the effective rate of 74 .55％ .The difference was statistically significant (P<0 .05) .The recovery time of the observation group was significantly less than that of the control group (P<0 .05) .The IL-6 and TNF-αlevels were decreased significantly in the observation group and the control group after the analgesia ,and the decrease level in the observation group was higher than that in control group (P<0 .05) .Besides ,IL-10 level in the observation group was significantly increased ,and the difference was statistically significant (P<0 .05) .After the analgesia ,BCS score and RSS score were significantly improved in the observation group and the effect is better than that in the control group (P<0 .05) .Conclusion The postoperative sedation effect of patient-controlled epidural analgesia is relatively good ,on elderly patients with hip arthroplasty ,and can effectively shorten the recovery time ,and regulate IL-6 ,IL-10 and TNF-αlevels .关键词
硬膜外自控镇痛/老年髋关节置换术/白细胞介素-6/白细胞介素-10/肿瘤坏死因子-αKey words
patient-controlled epidural analgesia/hip arthroplasty/inter leukin 6/inter leukin 10/tumor necrosis factor引用本文复制引用
刘辉,李丕彬,韩景田,关芳,张宪宦..硬膜外自控镇痛对老年髋关节置换术患者术后镇痛效果及IL-6、IL-10和TNF-α的影响[J].检验医学与临床,2017,14(24):3626-3628,3.
