临床口腔医学杂志2017，Vol.33Issue(12)：723-726,4.DOI:10.3969/j.issn.1003-1634.2017.12.005
血浆外泌体上调bFGF促体外微血管网形成的研究
The promoting effect of exosome from plasma to bFGF and angiogenesis in vitro
摘要
Abstract
Objective:This study was aimed to explore the effect of exosome from plasma to angiogenesis in endothe-lial cells( EC) in vitro. Methods:Exosome isolated from rabbit plasma was used to cultivate EC,observe the tube network for-mation,and detect the expression of basic fibroblast growth factor( bFGF) and vascular endothelial growth factor( VEGF) . Re-sults:Compared to control group,the experimental group had more tube network formation,higher expression and secretion of bFGF at 72 h,respectively(P <0. 001,P <0. 01). No statistical difference was found when comparing the expression of VEGF(P>0. 05). Conclusion:Exosome from plasma has up-regulation effect to bFGF and can promote angiogenesis in EC.关键词
外泌体/微血管生成/碱性成纤维细胞生长因子(bFGF)Key words
Exosome/Angiogenesis/Basic fibroblast growth factor( bFGF)分类
生物科学引用本文复制引用
古霞,姚洋,黄波,唐海洋,廖文,宫苹..血浆外泌体上调bFGF促体外微血管网形成的研究[J].临床口腔医学杂志,2017,33(12):723-726,4.基金项目
国家自然科学基金(81170995) （81170995）
四川大学青年教师科研启动基金(2016SCU11057) （2016SCU11057）
四川大学华西口腔医院青年科学研究基金(WCHS-201514) （WCHS-201514）
