临床误诊误治2017，Vol.30Issue(12)：70-73,4.DOI:10.3969/j.issn.1002-3429.2017.12.028
老年冠心病慢性心力衰竭患者血浆同型半胱氨酸与心脏功能的相关性
Correlation of Serum Homocysteine and Cardiac Function in Chronic Heart Failure Elderly Patients with Coronary Atherosclerotic Heart Disease
摘要
Abstract
Objective To observe correlation between serum homocysteine (Hcy) levels and cardiac function in chronic heart failure ( CHF) elderly patients with coronary atherosclerotic heart disease ( CAD) . Methods A total of 62 eld-erly patients with CAD were selected as CAD group, and the patients were divided into CHF subgroup (n=42) and cardiac function compensatory subgroup (n=20) according to cardiac function classification criteria from New York Heart Association ( NYHA) , and then CHF subgroup were divided into NYHA grade Ⅱ subgroup and NYHA grade Ⅲ-Ⅳ subgroup; other 20 healthy elderly patients taking medical examination at the same period were selected as control group. Changes of serum Hcy, n-terminal pro-b-type natriuretic peptide ( NT-proBNP) , left ventricular ejection fraction ( LVEF) and left ventricular end di-astolic dimension ( LVEDD) were compared, and correlations between serum Hcy levels with NT-proBNP, LVEF and LVEDD were analyzed in all groups and subgroups. Results Compared with those in control group, serum Hcy and NT-proBNP levels in compensatory and CHF subgroups and LVEDD level in CHF subgroup were significantly increased, while LVEF level in CHF subgroup was decreased (P <0. 05). Compared with those in compensatory subgroup, serum Hcy, NT-proBNP and LVEDD levels were significantly increased, while LVEF level was significantly decreased in CHF subgroup (P <0. 05). There were significant differences in serum Hcy and NT-proBNP levels between NYHA grade Ⅱ and NYHA gradeⅢ-Ⅳsub-groups (P<0. 05). Serum Hcy level in CHF elderly patients with CAD were positively correlated with NT-proBNP and LVEDD levels, and negatively correlated with LVEF level. Conclusion Serum Hcy level in CHF elderly patients with CAD significantly increases, and it is significantly correlated with NT-proBNP, LVEF and LVEDD levels, which can be used as an index in reflection of severity of heart failure.关键词
冠心病/心力衰竭/同型半胱氨酸Key words
Coronary disease/Heart failure/Homocysteine分类
医药卫生引用本文复制引用
朱红,马丽娜,刘川,杨伟,李耘,钱玉英..老年冠心病慢性心力衰竭患者血浆同型半胱氨酸与心脏功能的相关性[J].临床误诊误治,2017,30(12):70-73,4.基金项目
教育部人文社会科学研究青年项目基金(12YJCZH146) （12YJCZH146）
