日用化学工业2017，Vol.47Issue(3)：153-158,6.DOI:10.13218/j.cnki.csdc.2017.03.007
催化合成美白剂4-(1-苯乙基)-1,3-苯二酚及其性能研究
Synthesis and performance of a skin-whitening agent 4-(1-phenethyl)-1 ,3-benzenediol
徐源鸿 1许虎君1
作者信息
- 1. 江南大学化学与材料工程学院,江苏无锡 214122
- 折叠
摘要
Abstract
A skin-whitening agent,4-(1-phenethyl)-1,3-benzenediol was prepared by catalytic synthesis with styrene and resorcinol as starting materials. The catalyst,silicon supported phosphotungstic acid was prepared by pickling process and characterized by IR,XRD and SEM. The synthesized crude product was purified by re -crystallization in xylene as solvent;and structure of the product was identified by MS and 1 H NMR. Its skin -whitening activity and antioxidation activity were evaluated by using tyrosinase activity inhibition test,Fe3+ reducing capacity test as well as free radical inhibition test. Results showed that,the IC50 of the tyrosinase inhibition of the product is 0. 0105 g/L,which is much smaller than that ofβ-arbutin (IC50 =0. 64 g/L),and it means that the skin-whitening capacity of the product is conspicuously stronger than that ofβ-arbutin. Similarly,the EC50 of the capacity for Fe3+ reduction is 0. 033 g/L;the EC50 of the capacity for hydroxyl free radical removal is 0. 06 g/L;the EC50 of the capacity for superoxide free radical removal is 0. 32 g/L;results indicates that the capacity for Fe3+ reduction and superoxide free radical removal of the product are stronger than that of β-arbutin.关键词
美白剂/合成/抗氧化Key words
skin-whitening agent/synthesis/antioxidation分类
化学工程引用本文复制引用
徐源鸿,许虎君..催化合成美白剂4-(1-苯乙基)-1,3-苯二酚及其性能研究[J].日用化学工业,2017,47(3):153-158,6.
