陕西中医2018，Vol.39Issue(1)：6-9,13,5.DOI:10.3969/j.issn.1000-7369.2018.01.004
牛至草醇提物的抗氧化与抗炎、止咳祛痰作用研究
Effects of ethanol extract from Origanum valgare antioxidation and anti-inflammation ,antitussive and expectorant
摘要
Abstract
Objective:To study the antioxidant and antiinflammatory,antitussive and phlegm effects of etha-nol extract of Nile.Methods:NZEt was prepared with 95％ ethanol.The antioxidant effects of NZEt were studied by DPPH·hydroxyl radical,reducing ability and detection method.The total flavonoids and total polyphenols were determined.Swelling test,ammonia-induced cough test and bronchial phenol red excretion test,to explore its anti-in-flammatory,cough,expectorant effect.Results:NZEt had a clear activity against three free radicals,and all of them increased gradually with the increase of concentration.The highest concentration (2 mg/ml) cleared DPPH · The a-bility to close to the same concentration of VC,and its removal of the OH ability,the reduction capacity was less than the same concentration of VC.The total flavonoids and polyphenol contents of NZEt were 46.92mg /g and 32.64mg /g,respectively.it can inhibit the swelling of ear (P<0.05) and reduce the number of cough caused by am-monia spray (P<0.05),and promote the phenol red excretion (P<0.05).High and medium dose NZEt cough,ex-pectorant effect is better than the positive control drug acute syrup (P<0.05).Conclusion:NZEt has more signifi-cant antioxidant activity in vitro and anti-inflammatory,cough and expectorant.关键词
@牛至草醇提物/动物,实验/小鼠Key words
@Antioxidant/Animal experimentation/Mice分类
医药卫生引用本文复制引用
早克然·司马义,麦合苏木·艾克木,于洋,阿不都热依木·玉苏甫..牛至草醇提物的抗氧化与抗炎、止咳祛痰作用研究[J].陕西中医,2018,39(1):6-9,13,5.基金项目
新疆维吾尔自治区中医民族医药管理局人才培养计划项目(2016-30-14) （2016-30-14）
