陕西医学杂志2018，Vol.47Issue(1)：102-104,3.DOI:10.3969/j.issn.1000-7377.2018.01.034
双嘧达莫辅助丙种球蛋白及阿司匹林治疗川崎病对患儿抗血小板聚集因子及疗效影响研究
Clinical analysis of different doses of gamma globulin intravenous injection combined with Aspirin in children with Kawasaki disease
摘要
Abstract
Objective:To analyze the clinical effect of different doses of gamma globulin (IVIG) combined with Aspirin in the treatment of childhood Kawasaki disease (KD) .Methods:45 patiences with KD were divided in-to three groups randomly .The cases of group A were treated with 400 mg/(kg · d) IVIG for 5 days ,and group B received single dose of 1g/(kg · d) for 2 days ,and group C received single-dose of 2g /(kg · d) .The children of three groups were treated with aspirin .The hospitalization time and clinical symptoms subsided time was recorded in detail of all children ,the levers of platelet count (PLT ) ,white blood cell count (WBC) ,erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) four inflammatory changes were recorded before and after treatment of tree groups ;and the coronary artery injury and the treatment of efficiency were recorded with each group .Results :Com-pared with group A ,the hospitalization time and clinical symptoms subsided time of group B and group C were both significantly shortened ,and the four inflammatory indexes were significantly better than group A (P<0 .05) ,but there was no significant difference betweeen group B and group C in the hospitalization time ,clinical symptoms subsi-ded time and the four inflammatory indexes (P>0 .05) .The incidence rate of coronary artery injury in group C was significantly lower than that in group A(P<0 .05) ,and there was no significant difference of the coronary artery in-jury incidence rate between group B and group A ,group B and group C(P>0 .05) .There was no significant differ-ence in the total effective rate between group B and group C (P>0 .05) ,but there was a significant difference between group B and group A ,group C and group A(P<0 .05) .Conclusion :High-dose IVIG combined with Aspirin in chil-dren with Kawasaki disease treatment has significant effect ,can effectively reduce hospitalization and clinical symp-toms subsided time ,inhibit the release of inflammatory cytokines ,reduce the incidence of coronary artery injury .关键词
黏膜皮肤淋巴结综合征/药物疗法/丙种球蛋白类/治疗应用/阿司匹林/治疗应用Key words
Mucocutaneous lymph node syndrome/drug therapy/Gamma globulin/therapeutic use/Aspi-rin /therapeutic use分类
医药卫生引用本文复制引用
邹娜..双嘧达莫辅助丙种球蛋白及阿司匹林治疗川崎病对患儿抗血小板聚集因子及疗效影响研究[J].陕西医学杂志,2018,47(1):102-104,3.基金项目
国家自然科学基金资助项目(81303147) （81303147）
