摘要
Abstract
Objective :To analyze the effects of liraglutide combined with metformin on the immune response in patients with type 2 diabetes mellitus .Methods :150 patients with type 2 diabetes mellitus were randomly divided into experimental group and control group according to the order of admission ,75 cases in each group .The control group was treated with metformin ,and the treatment group was treated with liraglutide combined with metformin . Statistical analysis was performed using SPSS20 .0 statistical software .The clinical effects ,average body mass in-dex ,blood glucose level (2-hour postprandial blood glucose ,glycosylated hemoglobin ,fasting blood glucose) ,im-munoglobulin level (IgA ,IgG ,IgM) and the incidence of adverse reactions such as parameters .Results:① There was no significant difference in body mass index (BMI) ,2-hour postprandial blood glucose ,glycosylated hemoglo-bin ,fasting blood glucose ,IgA ,IgG and IgM levels between the two groups before treatment (P>0 .05) .After treatment ,(P<0 .05) .The average body mass index (BMI) ,2-hour postprandial blood glucose ,glycosylated he-moglobin (HbA1c) and fasting blood glucose were significantly higher in the experimental group than those in the control group (P< 0 .05) .The total effective rate of the experimental group was 94 .67% (71/75) ,the total effec-tive rate of the control group was 77 .33% (58/75) ,the total effective rate of the experimental group was much higher than the control group (P< 0 .05 );③ The adverse reaction rate was 4 .00% (3/75) in the experimental group and 5 .33% (4/75) in the control group .There was no significant difference in adverse reactions between the two groups (P>0 .05) .Conclusion :The efficacy of liraglutide combined with metformin in the treatment of type 2 diabetes mellitus is significant ,and at the same time ,it can effectively improve the immune function .关键词
糖尿病,2型/药物疗法/二甲双胍/治疗应用/胰高血糖素/治疗应用/@利拉鲁肽Key words
Diabetes mellitus,type 2/drug therapy/Metformin/therapeutic use/Glucagon/therapeutic use/@ Liraglutide分类
医药卫生
