摘要
Abstract
Objective To compare the perioperative parameters of patients with early non-small-cell lung cancer (NSCLC) undergoing video-assisted thoracoscopic surgery or open pulmonary lobectomy.Methods Forty-six patients with early-stage NSCLC undergoing surgical treatment were enrolled in the study,including 21 cases receiving video-assisted thoracoscopic surgery (study group) and 25 cases receiving open pulmonary lobectomy (control group).The perioperative parameters of two groups were compared,including the volume of intraoperative blood loss,the time length of drainage tube placement,the time length of operation,the number of lymph node clearance,the length of hospital stay,and the incidence of postoperative complications.The serum C reactive protein (CRP),tumor necrosis factor α (TNF-o),interleukin 6 (IL-6),amyloid A (SAA),blood glucose (GLU),white blood cell count (WBC),and serum prealbumin (PA) were measured before and after operation in two groups.Results The intraoperative blood loss,drainage tube placement time,hospitalization time and complication rate were all significantly lower in the study group than those in the control group (all P ＜0.05).However,there were no significant differences in the number of lymph nodes dissected and operation time between two groups (both P ＞ 0.05).The serum levels of inflammatory factors were increased after surgery in both groups (all P ＜ 0.05),while the levels were comparatively lower in the study group than those in the control group (P ＜ 0.05).The levels of WBC and GLU were lower and the level of PA was higher after surgery in the study group than those in the control group (all P ＜ 0.05).Conclusions Video-assisted thoracoscopic surgery has advantages of less trauma,shorter hospitalization time and lower complication rate.It can also reduce the acute inflammatory response compared to open surgery in patients with early stage NSCLC.关键词
癌,非小细胞肺/外科学/肺肿瘤/外科学/胸腔镜检查/肺切除术/方法/手术期间/临床对照试验Key words
carcinoma, non-small-cell lung/surgery/lung neoplasms/surgery/thoracoscopy/pneumonectomy/methods/intraoperative period/controlled clinical trial分类
医药卫生
