生殖医学杂志2017，Vol.26Issue(12)：1187-1191,5.DOI:10.3969/j.issn.1004-3845.2017.12.005
不同促排卵方案对不明原因不孕患者行宫腔内人工授精结局的比较
Comparison of results of artificial intrauterine insemination by using different ovulation induction regimens in patients with unexplained infertility
王馥新 1张艳 1许咏乐 1李红1
作者信息
- 1. 南京医科大学附属苏州市立医院生殖与遗传中心,苏州 215000
- 折叠
摘要
Abstract
Objective:To compare the effects of different ovulation induction regimens on intrauterine insemination(IUI)outcomes in the patients with unexplained infertility.Methods:The clinical data of 1 280 cycles in 508 couples with less than 35 years oldtreated by IUI in the Reproductive and Genetic Center of the Suzhou Municipal Hospital from 2001 to 2015 were retrospective analyzed.According to whether the ovulation induction,the patients were divided into natural group(n=628 cycles)and ovulation induction group(n=652 cycles).The cycles in ovulation induction group were divided to 5 groups according to different ovulation regimens:clomiphene(CC) group (153 cycles),H MG group (126 cycles),letrozole (LE) group(132 cycles),CC+ HMG group(107 cycles),LE + HMG group (134 cycles).The clinical pregnancy rate,abortion rate,ectopic pregnancy rate and live birth rate were collected in the groups.The general data and the clinical outcome indicators were compared among the five groups.Results:The clinical pregnancy rate (12.73％ vs.8.76％)and live birth rate(10.43％ vs.7.48％)of ovulation induction combined with IUI group were significantly higher than those of natural cycle.The pregnancy rate and live birth rate of LE+HMG group (15.67％ and 14.93％),CC+HMG group(16.82％ and 13.08％)and HMG group (15.08 ％ and 14.29％)were significantly higher than those of LE group (8.33％ and 6.06 ％) and CC group(9.15％ and 5.88％)(P＜0.05),while LE+HMG group had more significantly lower abortion rate(4.76％),twins rate(4.76％) and ectopic pregnancy rate(0％) than the other groups(P＜0.05).Conclusions:Using letrozole and low dose of HMG for ovulation induction in IUI treatment for patients with unexplained infertility can obtain higher clinical pregnancy rate,lower multiple birth rate and abortion rate,which is the ideal program for the patients unexplained infertility with IUI treatment.关键词
宫腔内人工授精(IUI)/不明原因不孕症/促排卵Key words
Intrauterine artificial insemination(IUI)/Unexplained infertility/Ovulation induction引用本文复制引用
王馥新,张艳,许咏乐,李红..不同促排卵方案对不明原因不孕患者行宫腔内人工授精结局的比较[J].生殖医学杂志,2017,26(12):1187-1191,5.
