生殖医学杂志2017，Vol.26Issue(12)：1233-1237,5.DOI:10.3969/j.issn.1004-3845.2017.12.014
334例男性不育症患者精子DNA完整性与精液常规参数间的相关性分析
Analysis of correlation between sperm DNA integrity and routine semen parameters in 334 infertile males
摘要
Abstract
Objective:To investigate the correlation between sperm DNA integrity and semen routine parameters in infertile males,and explore the value of DNA integrity detection in evaluation of male fertility.Methods:The data of 334 infertile males who admitted to our andrology clinic from January 2015 to December 2016 were analyzed retrospectively.The patients were divided into three groups according to spermDNA fragmentationindex(DFI):group Ⅰ with DFI≤15％(n=192);group Ⅱ with 15％＜DFI＜30％(n=98);group Ⅲ with DFI≥30％(n=44).The sperm parameters including sperm concentration,forward motile sperm percentage,normal morphological percentage,and age & abstinence time were compared among the three groups.The correlation between DFI and semen parameters was analyzed.Results:There were no significant differences in age,sperm concentration and normal morphological percentage between the different DFI groups(P＞0.05),but abstinence duration and forward motile sperm percentage were significantly different (P ＜ 0.05).The DFI was positive correlated with abstinence duration(r=0.222,P＜0.05),and negatively correlated with forward motile sperm percentage(r=-0.457)and normal morphological sperm percentage(r=-0.147)(all P＜0.05).No correlation was found between DFI with age and sperm concentration(P＞0.05).Conclusions:Sperm DNA integrity is associated with semen parameters including forward motile sperm percentage & normal morphological sperm percentage and abstinence duration.It may provide more reference on semen analysis.关键词
男性不育/精子DNA完整性/精液常规参数/禁欲时间Key words
Male infertility/Sperm DNA integrity/Routine sperm parameters/Abstinence duration引用本文复制引用
季兴哲,杨杰,宋娟,周寒鹰,张洲,师娟子..334例男性不育症患者精子DNA完整性与精液常规参数间的相关性分析[J].生殖医学杂志,2017,26(12):1233-1237,5.基金项目
陕西省卫生厅科学研究基金(2010C07) （2010C07）
