天然产物研究与开发2017，Vol.29Issue(11)：1824-1830,7.DOI:10.16333/j.1001-6880.2017.11.003
龙胆苦苷纳米乳的制备工艺及质量安全性评价
Preparation and Evaluation of Quality and Security of Gentiopicroside Nanoemulsion
摘要
Abstract
The aim of this study was to optimize prescription of gentiopicroside nanoemulsion and evaluate its quality and security.Single-factor test and pseudo-ternary phase diagram were adopted to optimize prescription,optimal prescription was gentiopicroside/ethyl acetate/EL-35/absolute ethyl alcohol/Ultrapure water (1.77∶ 7.66∶ 5.94∶11.91∶ 72.71),the particle size of nanoemulsion was 23.08 nm;The content of gentiopicroside was determined by HPLC;Stability of prepared gentiopicroside nanoemulsion was good in the state of different temperatures,illumination intensity and humidity conditions;The security test demonstrated that there was no acute toxicity;The optimized preparation technology of gentiopicroside nanoemulsion was simple,repeatable and stable.It provided the possibility to improve the bioavailability and clinical application.关键词
龙胆苦苷/纳米乳/制备工艺/质量评价Key words
gentiopicroside/nanoemulsion/preparation technology/quality evaluation分类
医药卫生引用本文复制引用
夏鹏飞,马肖,吴国泰,李阳,樊秦,赵磊..龙胆苦苷纳米乳的制备工艺及质量安全性评价[J].天然产物研究与开发,2017,29(11):1824-1830,7.基金项目
国家自然科学基金(81660577) （81660577）
2014年度中医学院中青年科研基金(ZQ2014-2) （ZQ2014-2）
甘肃省科技计划(148RJZA064) （148RJZA064）
甘肃省中药药理与毒理学重点实验室自主基金(ZDSYS-KJ-2016-008) （ZDSYS-KJ-2016-008）
西北民族大学科研项目(31920160115) （31920160115）
甘肃省科技计划(148RJZA064) （148RJZA064）
