天然产物研究与开发2017，Vol.29Issue(11)：1851-1857,7.DOI:10.16333/j.1001-6880.2017.11.007
滋肾清肝方对2型糖尿病模型大鼠的药效及作用机制
Effect and Mechanism of Zishenqinggan Prescription on Type 2 Diabetes Model Rat
摘要
Abstract
This study is to investigate the effect and mechanism of Zishenqinggan prescription (ZSQG) on the treatment of type 2 diabetes,and lay the foundation for its clinical application and further development.T2DM model rats were randomly divided into model group,metformin group,high,middle,low dose of ZSQG group.The effect of ZSQG on body weight,food intake,water intake,urine,stool,blood glucose,OGTT,HbAlc,C-peptide,GLP-1 content,GSP,insulin of rats was studied;Western blot was used to detect AKT,p-AKT,GSK-3β,p-GSK-3β expression in liver tissue and to detect pIRS-1,IRS-1,Glut4 expression in skeletal muscle tissue.ZSQG can effectively regulate sugar metabolic disorders in type 2 diabetic model rat,improve insulin resistance;enhance insulin secretion,regulate skeletal muscle PI3K/AKT,regulate liver AKT/GSK-3β signaling pathway,which may be the mechanism of ZSQG for the treatment of type 2 diabetes and to improve insulin resistance.关键词
滋肾清肝方/2型糖尿病/药效/作用机制Key words
Zishenqinggan prescription/type 2 diabetes mellitus/effect/mechanism分类
医药卫生引用本文复制引用
田春雨,张碧溦,徐雪梅,薄海美,曹岩,杨雨旸,喇孝瑾,郭兰,贾永森,李继安,李洁..滋肾清肝方对2型糖尿病模型大鼠的药效及作用机制[J].天然产物研究与开发,2017,29(11):1851-1857,7.基金项目
科技部国际科技合作项目(2008DFA31050) （2008DFA31050）
河北省中医药管理局科研计划(2016070) （2016070）
