天然产物研究与开发2017，Vol.29Issue(11)：1867-1872,1881,7.DOI:10.16333/j.1001-6880.2017.11.009
美洲大蠊抗氧化活性成分研究
Antioxidant Constituents from Periplaneta americana
摘要
Abstract
To study the chemical constituents from 95％ ethanol extract of Periplaneta americana.The chemical constituents were isolated and purified by silica gel column chromatography,Sephadex LH-20 column chromatography,0DS column chromatography and semi-preparative HPLC.Fourteen compounds were obtained from the ethyl acetate fraction of P.americana based on NMR and MS spectroscopic methods.Their structures were identified as cyclo (L-Val-L-Pro) (1),3,4-dihydroxyphenylethanol (2),protocatechuic acid (3),cyclo (L-Ile-L-Pro) (4),cyclo (L-Phe-L-Val) (5),nicotinic acid (6),hippuric acid (7),aspongpyrazine A (8),aspongopusin (9),(2R,3S)-2-(3',4'-dihydroxyphenyl)-3-acetylamino-7-hydroxyethyl-1,4-benzodioxane (10),(2R,3S)-2-(3',4'-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2"-aminoethylene)-1,4-benzodioxane (11),cyclo (Leu-Pro) (12),1,2-dehydro-N-acetyldopamine (13) and 3,4-dihydro-8-hydroxy-2(1 H)-quinolinone(14).Among them,compounds 1,4-9 and 10-13 were isolated from the genus for the first time.The spectral data of compound 10 were reported for the first time.All compounds were evaluated for antioxidant activity.Compounds 2,3 and 13 showed potential antioxidant activity by DPPH and ABTS+ radical scavenging methods.关键词
美洲大蠊/化学成分/结构鉴定/抗氧化活性Key words
Periplaneta americana/chemical constituents/structural elucidation/antioxidant activity分类
医药卫生引用本文复制引用
张涛,司金光,陈佳欢,张秋博,邹忠梅..美洲大蠊抗氧化活性成分研究[J].天然产物研究与开发,2017,29(11):1867-1872,1881,7.基金项目
中国医学科学院医学与健康科技创新工程(2016-12M-3-015) （2016-12M-3-015）
