天然产物研究与开发2017，Vol.29Issue(11)：1873-1876,4.DOI:10.16333/j.1001-6880.2017.11.010
千根草化学成分研究Ⅱ
Chemical Constituents of Whole Plant of Euphorbia thymifolia Ⅱ
摘要
Abstract
The aim of this study was to investigate the chemical constituents of the whole plant of Euphorbia thymifolia L.and to investigated the cytotoxic activities of the isolated compounds.The constituents were isolated and purified from E.thymifolia by various column chromatography.Their structures were elucidated by NMR and HR-ESI-MS and identified as secoisolariciresinol (1),dihydrodehydrodiconiferyl alcohol (2),3-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl] propyl acetate (3),3,3'-bis (3,4-dihydro-4-hydroxy-6-methoxy-2H-l-benzopyran) (4),apigenin-7-O-β-D-glucopyranside (5),butylbrevifolin carboxylate (6) and apigenin (7).Compounds 1-6 were isolated from this plant for the first time.MTT assays were performed to detect the viability of Huh7.5 and A549 cells by different concentrations of drugs (compounds 1-4 and 6).When the concentration of the drugs was 40 μMol/L,compound 6 significandy reduced the proliferation of two cells.关键词
千根草/化学成分/木脂素/黄酮Key words
Euphorbia thymifolia L./chemical constituents/lignans/flavonoid分类
医药卫生引用本文复制引用
雷翔,盛亚丽,王红刚..千根草化学成分研究Ⅱ[J].天然产物研究与开发,2017,29(11):1873-1876,4.基金项目
广东省省级科技计划(2016A070712021) （2016A070712021）
