天然产物研究与开发2017，Vol.29Issue(11)：1877-1881,5.DOI:10.16333/j.1001-6880.2017.11.011
紫红獐牙菜中的(口山)酮类成分及其细胞毒活性
Xanthones from Swertia punicea and Their Cytotoxic Activity
摘要
Abstract
The xanthones from Swertia punicea and their cytotoxic activities were investigated in this study.The petroleum ether and ethyl acetate part of ethanol extracts from S.punicea were separated by chromatographic techniques.The structures of these compounds were identified by1H NMR,13C NMR,HSQC,HMBC and ESI-MS data,eight xanthones were isolated from this plant,they were 1-hydroxyl-2,3,5,7-tetramethoxyxanthone (1),1,2,3,4,5-pentamethoxythone (2),1-hydroxyl-2,3,4,7-tetramethoxyxanthone (3),1-hydroxyl-2,3,5-trimethoxyxanthone (4),dulcisxanthone C (5),1-hydroxyl-2,3,7-trimethoxyxanthone (6),1,5-dihydroxy-2,3-dimethoxyxanthone (7) and 1-hydroxyl-3,4,5-trimethoxyxanthone (8),all of these compounds were isolated for the first time from S.punicea.The cytotoxic activities of these compounds were also evaluated,and compound 1,4,5,7 showed good cytotoxic activities against HepG-2.关键词
紫红獐牙菜/(口山)酮/细胞毒活性/二维核磁共振Key words
Swertia punicea/xanthone/cytotoxic activity/2D NMR分类
医药卫生引用本文复制引用
雷声,郭青,王明锋,刘文星,牟林云,李干鹏..紫红獐牙菜中的(口山)酮类成分及其细胞毒活性[J].天然产物研究与开发,2017,29(11):1877-1881,5.基金项目
云南中烟工业有限责任公司,烟草行业卷烟调香技术重点实验室科研项目(JSZX20151008-52) （JSZX20151008-52）
