心理科学进展2017，Vol.25Issue(12)：2013-2020,8.
内质网应激与创伤后应激障碍
Endoplasmic reticulum stress and posttraumatic stress disorder
摘要
Abstract
Endoplasmic reticulum stress (ERS) induce the protein folding reaction, and then make endoplasmic reticulum three pathway PERK, IRE1 and ATF6 separate from the endoplasmic reticulum chaperone, activate of three pathways and start the apoptosis pathway. We used the animal model of posttraumatic stress disorder: single prolonged stress (SPS) to find endoplasmic reticulum stress cause the endoplasmic reticulum chaperone and protect neurons at the early stage of SPS, but in the later period of SPS, when the ability decreased that endoplasmic reticulum chaperone correct for the folding protein, ERS could accelerate the activation of three path and induce the cell apoptosis.关键词
内质网应激/单程长时应激/PERK/IRE1/ATF6Key words
Endoplasmic reticulum stress/single prolonged stress/PERK/IRE1/ATF6分类
社会科学引用本文复制引用
韩芳,石玉秀,刘虹,肖冰,刘冬娟,温莉莉,赵伟,孔繁镇,赵冬梅,李笑岩..内质网应激与创伤后应激障碍[J].心理科学进展,2017,25(12):2013-2020,8.基金项目
国家自然科学基金项目(81571324). （81571324）
