心理科学进展2017，Vol.25Issue(12)：2021-2029,9.DOI:10.3724/SP.J.1042.2017.02021
应激对兴奋性突触传递的影响及其分子机制
Effect of stress on excitatory synaptic transmission and the molecular mechanisms
摘要
Abstract
Stress is strongly associated with depression, cardiovascular disorders and cancers. The prefrontal cortex and hippocampus are not only important regions regulating the stress response, but also the main targets of stress. Excitatory synaptic transmission plays an essential role in the brain function, which is affected by stress through altering the transmitter release and metabolism,and the expression and trafficking of postsynaptic receptors. Multiple intracellular molecular signal cascades are involved in the underlying mechanisms of the stress response. Thus, understanding these mechanisms may provide potential targets for discovering the novel therapeutic treatments of stress-associated disorders.关键词
应激/皮质激素及受体/内侧前额叶皮层/兴奋性突触传递/AMPA和NMDA受体Key words
stress/glucocorticoid and receptors/medial prefrontal cortex/excitatory synaptic transmission/AMPA and NMDA receptors分类
社会科学引用本文复制引用
李每易,王春莲,王子卿,陈焕新..应激对兴奋性突触传递的影响及其分子机制[J].心理科学进展,2017,25(12):2021-2029,9.基金项目
西南大学人才基金104530-20700907资助. （）
