心理科学进展2017，Vol.25Issue(12)：2030-2035,6.DOI:10.3724/SP.J.1042.2017.02030
早年应激影响成年海马神经元再生的机制
The mechanisms for the effects of early-life stress on adult hippocampal neurogenesis
摘要
Abstract
Adult hippocampal neurogenesis is a process of generating functional new neurons from neural precursors in the subgranular zone of the adult dentate gyrus. Exposure to severe stressful events early in life impairs adult hippocampal neurogenesis and disrupts learning and memory. Accumulating evidence has shown that glucocorticoid and its receptors play fundamental roles in the negative effects of early-life stress on adult hippocampal neurogenesis, yet the exact mechanisms and mediators remain to be investigated. Here, we highlight the potential roles of key stress mediators, including corticotropin-releasing hormone and its receptors, in modulating the negative effects of early-life stress on adult hippocampal neurogenesis and hippocampal plasticity.关键词
早年应激/齿状回/神经元再生/糖皮质激素/促肾上腺皮质激素释放激素Key words
early-life stress/dentate gyrus/neurogenesis/glucocorticoid/corticotropin-releasing hormone分类
社会科学引用本文复制引用
王兴兴,王晓东..早年应激影响成年海马神经元再生的机制[J].心理科学进展,2017,25(12):2030-2035,6.基金项目
中国自然科学基金面上项目(81471369)支持. （81471369）
