心理科学进展2017，Vol.25Issue(12)：2036-2042,7.
中枢免疫失衡与认知功能障碍:聚焦TNFα的作用
Imbalance of central immunity and cognitive dysfunction:The role of TNFα
摘要
Abstract
Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient, can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.关键词
内稳态/TNFα/应激/突触可塑性/认知功能Key words
homeostasis/Tumor necrosis factor (TNFα)/stress/synaptic plasticity/cognitive function分类
社会科学引用本文复制引用
张瑜,林文娟,王玮文..中枢免疫失衡与认知功能障碍:聚焦TNFα的作用[J].心理科学进展,2017,25(12):2036-2042,7.基金项目
国家自然科学基金(No.81471122andNo.31470988),中国科学院(KJZD-EW-L04)和中国科学院心理健康重点实验室(中国科学院心理研究所)资助. （No.81471122andNo.31470988）
