心理科学进展2017，Vol.25Issue(12)：2043-2056,14.DOI:10.3724/SP.J.1042.2017.02043
内源性大麻素与创伤后应激障碍:可能的作用机制与治疗应用
Endocannabinoid and post-traumatic stress disorder:Possible mechanisms and clinical application
摘要
Abstract
Recently, endocannabinoid system has been proposed as a new pharmacological target of post-traumatic stress disorder (PTSD). Empirical studies indicated that endocannabinoid system is closely linked to the occurrence and development of PTSD due to its important roles in regulating the fear memory, anxiety, depression, reward as well as motivation. Several clinical studies also found that appropriate dose of cannabinoids can relieve PTSD symptoms, especially the sleep problems. Future studies should further explore the pathological mechanism of endocannabinoid system in PTSD, increase the clinical security of medicinal cannabinoids,and develop the new kinds of cannabinoid receptor modulators. In addition, investigating of the influence of genetic factors and heterogeneity of responses in the effect of endocannabinoid on treatment of PTSD will also promote the early identification of the patients and the development of precision medicine.关键词
内源性大麻素/创伤后应激障碍/恐惧记忆/焦虑/抑郁Key words
endocannabinoid/post-traumatic stress disorder/fear memory/anxiety/depression分类
社会科学引用本文复制引用
朱叶,曹成琦,王力..内源性大麻素与创伤后应激障碍:可能的作用机制与治疗应用[J].心理科学进展,2017,25(12):2043-2056,14.基金项目
国家自然科学基金面上项目(31471004,31271099)、中国科学院对外合作重点项目(153111KYSB20160036). （31471004,31271099）
