心理科学进展2017，Vol.25Issue(12)：2057-2062,6.DOI:10.3724/SP.J.1042.2017.02057
DNA表观遗传修饰在药物成瘾记忆中的作用及机制
The role and mechanisms of DNA epigenetic modification in drug related memory
摘要
Abstract
DNA epigenetic modification includes DNA methylation, which was catalyzed by the DNA methyltransferase, and DNA demethylation, which was mediated by the Ten-eleven translocation enzymes. Both of them induce the changes of neural activity and behavior through responding environmental stimulus and regulating gene expression. Massive studies suggested that DNA methylation is one of the most important mechanisms in the drug related memory. In recent years, it was found that DNA demethylation involved in controlling fear memory and addiction behavior. As a result, the effects of DNA epigenetic modification on drug related memory should be reassessed. This review focuses on the co-regulation of DNA methylation and demethylation in drug related memory, then we discuss the probable regulatory mechanisms and try to put forward the vista of further study.关键词
DNA甲基化/DNA去甲基化/药物成瘾记忆Key words
DNA methylation/DNA demethylaiton/drug related memory分类
社会科学引用本文复制引用
张建军,蒋丰泽,隋南..DNA表观遗传修饰在药物成瘾记忆中的作用及机制[J].心理科学进展,2017,25(12):2057-2062,6.基金项目
国家重点基础研究发展计划(2015CB553501),国家自然科学基金(91332115 （2015CB553501）
31400880)资助. （）
