心理科学进展2017，Vol.25Issue(12)：2075-2081,7.
GABA能系统在应激诱发的抑郁症中的作用
The role of stress-induced GABAergic system alteration in depression
摘要
Abstract
γ-aminobutyric acid (GABA) is the most important inhibitory amino acid neurotransmitter in the central nervous system to maintain the excitatory-inhibitory balance of the brain. Increasing clinical and pre-clinical evidence shows a central and causal role of GABAergic deficits in depressive disorders. Depressive patients commonly indicate reduced GABAergic transmission in emotional and cognitive brain areas, especially prefrontal cortex and limbic areas like hippocampus and amygdala, and antidepressants can alleviate or reverse depressive symptoms by augmenting GABAergic activity in these areas. Furthermore, deficits in GABAergic transmission are sufficient to cause most of the neural and behavioral alterations expected in an animal model of depression. GABAergic system undergoes a prolonged development to structural and functional maturation until into early adulthood in both human and rodents. Stress, especially early stress, may disturb the mature trajectory of the GABAergic system, and result in continuing negative consequences of neural development and late functioning, which can contribute to the increased susceptibility for the onset of depression across late life. It would be important to further elucidate GABAergic mechanisms underlying depressive disorders and action of antidepressant in order to improve strategy for early recognition and intervention of depression.关键词
应激/GABA能系统/抑郁症Key words
stress/GABAergic/depression分类
社会科学引用本文复制引用
徐航,陈焕新,王玮文..GABA能系统在应激诱发的抑郁症中的作用[J].心理科学进展,2017,25(12):2075-2081,7.基金项目
国家自然科学基金(No.81471122andNo.31470988),中国科学院(KJZD-EW-L04)和中国科学院心理健康重点实验室(中国科学院心理研究所)资助. （No.81471122andNo.31470988）
