心理科学进展2017，Vol.25Issue(12)：2082-2088,7.DOI:10.3724/SP.J.1042.2017.02082
围产期抑郁引发代际性抑郁障碍及机制
Maternal peripartum depression induced transgenerational depressive disorder and mechanisms
摘要
Abstract
Peripartum depression (PPD) has adverse effects on both mothers and offpring, particularly by increasing the risk of emotional disorders in offspring significantly in a transgenerational manner. The pathogenesis of transgenerational depressive disorders from PPD is complex, and the current pharmacotherapeutic efficacy was limited. Therefore, it is of great importance to study the mechanisms underlying this disorder. We discuss the role of the hypothalamic-pituitary-adrenal axis (HPA), oxytocin (OT), synaptic plasticity and epigenetic mechanisms underlying transgenerational depressive disorders, to give insight for further in-depth research.关键词
围产期抑郁/代际遗传/影响机制/表观遗传学Key words
Peripartum depression (PPD)/transgenerational depression/mechanisms/Epigenetics分类
社会科学引用本文复制引用
吴如燕,夏宝妹,王薇,徐桂华,陈刚..围产期抑郁引发代际性抑郁障碍及机制[J].心理科学进展,2017,25(12):2082-2088,7.基金项目
国家自然科学基金(81673625) （81673625）
江苏自然科学基金(BK20151568) （BK20151568）
江苏省双创项目(2013455),江苏六大人才高峰项目(2013-YY-11) （2013455）
江苏省优势学科 （）
国家自然青年基金(81701340) （81701340）
江苏省省自然科学基金(BK20170517) （BK20170517）
江苏省省自然科学基金(BK20170769). （BK20170769）
