摘要
Abstract
Objective To explore the expression of the serum cystatin C (CysC) ,and chromograninA (CgA) in patients with chronic heart failure and its correlation with left ventricular mass index (LVMI).Methods 90 cases of chronic heart failure that were treated in our hospital ,were randomly taken as example ,including 30 cases of NYHA Class Ⅳ ,30 cases of NYHA Class Ⅲ ,and 30 cases of NYHA Class Ⅱ ,while 30 cases of normal physical examination as control group. The level of NT_proBNP ,CysC and CgA in all groups were tested ,and the left ventricular end_diastolicvolume (LVEDV) ,the left ventricular end_diastolic diameter(LVEDD) ,the left ventricular ejection fraction(LVEF) were measured. Based on the above results ,the final calculation of the left ventricular mass index(LVMI) was made. Results The LVMI and LVEDD level in patients with chronic heart failure were significantly higher than the control group ,while the level of LVEF was lower than the control group. The difference between the two groups was statistically sig-nificant (P< 0.05) ;With the increase of cardiac function level ,LVMI and LVEDD increased gradually ,while LVEF decreased. The difference between the two groups was statistically significant (P< 0.05) ;The level of CysC ,CgA and NT_proBNP in patients with chronic heart failure were significantly higher than the control group. After the comparison ,the difference was statistically signifi-cant (P< 0.05) ;The level of CysC ,CgA and NT_proBNP in patients with grade Ⅳ cardiac function were higher than those patients with Class Ⅱ and Ⅲ cardiac function ,and those with grade Ⅲ cardiac function were higher than those patients with Class Ⅱ cardiac function. And the difference was statistically significant (P< 0.05) ;The level of serum CgA and CysC in patients with chronic heart failure were negatively correlated with LVEF (r = -0.701 ,-0.687 ,P< 0.05) ,and were positively correlated with NT_proBNP and LVMI (r = 0.714 ,0.873 ,0.695 ,0.807 ,P < 0.05).Conclusions The level of CgA and CysC ,are correlated with cardiac function class in patients with chronic heart failure and ventricular remodeling ,and they can be used as an indicator to determine the degree of ventricular remodeling in patients with chronic heart failure.关键词
嗜铬粒蛋白A/心力衰竭/胱抑素C/心室重塑Key words
ChromograninA/Chronic heart failure/Cystatin C/Ventricular remodeling分类
医药卫生
